Hypermethylation of RASSF1A Promoter Is Associated with the Age at Starting Smoking and a Poor Prognosis in Primary Non-Small Cell Lung Cancer

摘要: Cigarette smoking is the most common cause of lung cancer. The greatest risk cancer among those who started early in life and continued throughout their lives. However, molecular mechanisms responsible for susceptibility to young smoker are not clear. Recently, several groups have reported that hypermethylation CpG islands associated with exposure tobacco smoke. We studied association between age at starting p14, p16, RASSF1A promoters 204 primary non-small cell patients. also examined whether promoter an independent prognostic factor. Methylation rates samples were detected 9% 27% 32% RASSF1A. There was no relationship p14 p16 smoking. found be significantly (P = 0.001). No methylation status other variables, such as pack-years, status, duration patients earlier than without (19 +/- 8 versus 25 7; P Young smokers before 19 4.23 times [95% confidence interval (CI) 1.03-9.67; 0.001] more likely after 19. Furthermore, a poor prognosis stages 1 2 0.02 0.01, respectively; Log-rank test). hazard failure approximately 3.27 higher (95% CI 1.42-8.71; 0.01). habit had poorer (hazard ratio 2.14, 95% 1.22-9.11; 0.02). Our results suggest cigarette may factor