Circulating microRNAs as diagnostic biomarkers for pancreatic cancer.

摘要: There is an urgent need for novel and reliable biomarkers the diagnosis prognostication of pancreatic ductal adenocarcinoma (PDAC). Circulating microRNAs (miRNAs) have been extensively profiled in PDAC blood samples, but few studies performed adequate validation candidate markers. The evaluated study by Xu et al. investigated pre-operative plasma miRNAs from patients over three phases surgical centers. They revealed miR-486-5p miR-938 were able to discriminate healthy controls those with chronic pancreatitis. diagnostic ability identifying was comparable that CA 19-9. This provides further evidence use blood-based as PDAC. However, these not identified previous require methodology needs be standardized if are ever used clinic.