Different mechanisms are responsible for oncogene activation in human mammary neoplasia.
作者： Matthias H. Kraus , Pier Paolo Di Fiore , Jacalyn H. Pierce , Stuart A. Aaronson
DOI: 10.1007/978-1-4613-1733-3_3
关键词: Human epidermal growth factor receptor 、 Gene 、 Genome 、 Biology 、 Oncogene Activation 、 Cancer research 、 Neoplastic transformation 、 Cell biology 、 Viral Genes
摘要: Investigations of genetic alterations associated with neoplasia have identified a limited set cellular genes, termed proto-oncogenes, that are highly conserved in vertebrate evolution. Acute transforming retroviruses substituted viral genes essential for replication these discrete segments host information. When incorporated within the retroviral genome, such transduced sequences acquire ability to induce neoplastic transformation as oncogenes, an observation initially linked process [1, 2].
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