Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat.

摘要: Brown adipose tissue (BAT), an important endocrine organ long known for thermogenesis and energy consumption, has received much attention in recent years its potential to combat obesity. In general, BAT can enhance metabolism improve overall health. Our work demonstrates the ability of embryonic transplants correct type 1 diabetes (T1D) without insulin, via mechanisms somewhat different from those involved BAT-associated weight loss. seem reverse T1D by decreasing inflammation increasing functionality surrounding white (WAT), thereby enabling it secrete hypoglycemic adipokines, which compensate function insulin. Thus transform unhealthy WAT a healthy status, sufficient replace pancreas establish insulin-independent glycemic regulation. Several studies, including ours, demonstrate remarkable metabolic disorders hint at beneficial effects on inflammation. Hence, addition more body, through transplantation or stimulating regeneration, may well be therapy future simple correction numerous diseases.