SERINE PHOSPHOLIPIDS IN CELL COMMUNICATION

摘要: Communication between distant cells depends on the release of signals in intercellular space. These (first messengers) are collected by receptors located external cell membrane a target and then transduced interior through perturbation second messenger system. Phospholipids, as components plasma membrane, participate this signalling Cycles polyphosphoinositide degradation resynthesis response to activation generate messengers diacylglycerol inositol trisphosphate (Berridge Irvine, 1984). Since 1976, when first pharmacological effects phosphatidylserine (PdtSer) vivo were described (Bruni et al., 1976), our efforts have aimed at exploring whether serine phospholipids involved system communication. As shown Figure 1, basic assumption hypothesis is that PtdSer held inner side order avoid exposure headgroup environment. observations Verkleij al. (1973) Gordesky Marinetti (1973), many studies confirmed hidden position preferred distribution eukaryotic cells. When broken, exposed lysoPtdSer may be generated. two phospholipids, either damaged (Ptd Ser) or free monomers solution (lysoPtdSer) reach responsive adjustment repair requested. To establish effect least three criteria must fulfilled: (a) generation upon damage, (b) existence binding sites for sensitive (c) functional following interaction these compounds with cell.