Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.

摘要: ErbB-2/HER2 is an oncogenic tyrosine kinase that regulates a signalling network by forming ligand-induced heterodimers with several growth factor receptors of the ErbB family. Hsp90 and co-chaperones regulate degradation ErbB-2 but not other members. Here, we report role in modulating extends beyond regulation protein stability. The capacity to recruit ligand-bound into active limited Hsp90, which dissociated from following heterodimerization. We show binds specific loop within domain ErbB-2, thereby restraining heterodimer formation catalytic function. These results define for as molecular switch regulating limiting ErbB-2-centred receptor complexes.