IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

摘要: Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is regulatory cytokine that has been suggested for treatment of asthma because its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate model allergic sensitization mice deficient (IL-10−/−) develop pulmonary response but fail exhibit hyperresponsiveness both vitro vivo assessments lung function. Reconstitution with the gene fully restores development comparable control mice. These results identify IL-10, downstream cascade, regulating tone airways after challenge.