Contribution of the extracellular matrix to the viscoelastic behavior of the urinary bladder wall

摘要: We previously reported that when the stress relaxation response of urinary bladder wall (UBW) tissue was analyzed using a single continuous reduced func- tion (RRF), we observed non-uniformly distributed, time- dependent residuals (Ann Biomed Eng 32(10):1409-1419, 2004). concluded spectrum inadequate and new viscoelastic model for necessary. In present study, report approach composed independent RRFs smooth mus- cle extracellular matrix components (ECM), con- nected through stress-dependent recruitment function. order to determine RRF ECM component, biax- ial experiments were first performed on decellularized network obtained from normal spinal cord injured rats. While it assumed muscle followed RRF, modeling UBW required dual-Gaussian spectrum. Experimental results revealed insensitive initial level. Thus, average parameters determined by fitting data. The resulting behavior whole mod- eled combining with component an exponential function representing collagen fibers at higher levels. summary, study demon- strated, time, can be better modeled divided into contributions components. This is suitable predic- mechanical behaviors other organs exhibit rapid remodeling (i.e., hypertrophy altered synthesis) under various pathological conditions.