Ras regulation of vascular endothelial growth factor and angiogenesis.

摘要: Given the multifaceted role of Ras in tumor angiogenesis, pharmacologic targeting such proteins may bring about at least three important consequences: (1) partial obliteration angiogenic competence cells, (2) an increase vascular dependence and sensitization to apoptosis, (3) a direct inhibition endothelial cell responses proangiogenic stimuli. Exploration some these possibilities, using various pharmacological compounds antibodies, has already begun. An intriguing possibility is that antagonists signal transduction inhibitors synergize with number other antiangiogenic modalities as acting agents (e.g., endostatin) or antivascular regimens involving low-dose continuous chemotherapy vasculature-targeting strategy.