Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
作者： Jer-Hwa Chang , Chao-Wen Cheng , Yi-Chieh Yang , Wan-Shen Chen , Wen-Yueh Hung
DOI: 10.1186/S13046-018-0869-1
关键词: Apigenin 、 Cancer 、 Apoptosis 、 Metastasis 、 Snail 、 Lung cancer 、 Protein kinase B 、 Medicine 、 Cancer research 、 Slug
摘要: Background Metastasis rather than the primary cancer determines survival of patients. Activation Akt plays a critical role in epithelial-to-mesenchymal transition (EMT), initial step lung metastasis. Apigenin (API), flavonoid with potent Akt-inhibitory effect, shows oncostatic activities various cancers. However, effects API on metastasis non-small cell (NSCLC) remain unclear.
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sci-hub.se 参考文章(58)
Pamela A Havre, Masako Abe, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Nam H Dang, The role of CD26/dipeptidyl peptidase IV in cancer Frontiers in Bioscience. ,vol. 13, pp. 1634- 1645 ,(2008) , 10.2741/2787
Jae-Hwi Jang, Lesley Baerts, Yannick Waumans, Ingrid De Meester, Yoshito Yamada, Perparim Limani, Ignacio Gil-Bazo, Walter Weder, Wolfgang Jungraithmayr, Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice Clinical & Experimental Metastasis. ,vol. 32, pp. 677- 687 ,(2015) , 10.1007/S10585-015-9736-Z
Jin Young Kim, Young Mee Kim, Chang Hee Yang, Somi K. Cho, Jung Weon Lee, Moonjae Cho, Functional regulation of Slug / Snail2 is dependent on GSK‐3β‐mediated phosphorylation FEBS Journal. ,vol. 279, pp. 2929- 2939 ,(2012) , 10.1111/J.1742-4658.2012.08674.X
Sen-itiroh Hakomori, Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens Advances in Cancer Research. ,vol. 52, pp. 257- 331 ,(1989) , 10.1016/S0065-230X(08)60215-8
Lindsay J Talbot, Paul C Kuo, Syamal D Bhattacharya, Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies. International journal of biochemistry and molecular biology. ,vol. 3, pp. 117- 136 ,(2012)
Wenting Xu, Zhen Yang, Nonghua Lu, A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition. Cell Adhesion & Migration. ,vol. 9, pp. 317- 324 ,(2015) , 10.1080/19336918.2015.1016686
Veronica Henderson, Basil Smith, Liza J Burton, Diandra Randle, Marisha Morris, Valerie A Odero-Marah, Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adhesion & Migration. ,vol. 9, pp. 255- 264 ,(2015) , 10.1080/19336918.2015.1013383
Chen-Wei Liu, Ching-Hao Li, Yi-Jen Peng, Yu-Wen Cheng, Huei-Wen Chen, Po-Lin Liao, Jaw-Jou Kang, Mao-Hsiung Yeng, Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer Oncotarget. ,vol. 5, pp. 3880- 3894 ,(2014) , 10.18632/ONCOTARGET.2006
O Acuto, E L Reinherz, S F Schlossman, J F Daley, R E Hussey, K A Fitzgerald, C Poole, L Palley, D A Fox, Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. Journal of Immunology. ,vol. 133, pp. 1250- 1256 ,(1984)
LINGMEI LI, LISHA QI, ZHIJIE LIANG, WANGZHAO SONG, YANXUE LIU, YALEI WANG, BAOCUN SUN, BIN ZHANG, WENFENG CAO, Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells International Journal of Molecular Medicine. ,vol. 36, pp. 113- 122 ,(2015) , 10.3892/IJMM.2015.2222