Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis.
作者： Moussa Labsi , Lila Khelifi , Dalila Mezioug , Imene Soufli , Chafia Touil-Boukoffa
DOI: 10.1016/J.APJTM.2016.01.038
关键词: Echinococcosis 、 Nitric oxide 、 Cyst 、 CD68 、 Murine model 、 Punica 、 Aqueous extract 、 Pharmacology 、 Traditional medicine 、 Echinococcus granulosus 、 Medicine
摘要: Abstract Objective To investigate the effect of pomegranate peel aqueous extract (PGE) on development secondary experimental echinococcosis and viability Echinococcus granulosus protoscoleces, immunomodulatory properties PGE. Methods Swiss mice were inoculated intraperitoneally with viable protoscoleces. Then, PGE was orally administered daily during cystic development. Cyst hepatic damage macroscopically histologically analyzed. The production nitric oxide TNF-α assessed in plasma expression iNOS, TNF-α, NF-κB CD68 examined. Moreover, protoscoleces cultured treated different concentrations Results It observed that in vitro treatment caused a significant decrease PGE-dose-dependent manner. In vivo , after infected PGE, levels ( P Conclusions Our results indicate an antihydatic scolicidal suggesting its potential therapeutic role against infection.
sci-hub.se 参考文章(42)
M. Urrea-París, M. Moreno, N. Casado, F. Rodríguez-Caabeiro, Relationship between the efficacy of praziquantel treatment and the cystic differentiation in vivo of Echinococcus granulosus metacestode Parasitology Research. ,vol. 88, pp. 26- 31 ,(2002) , 10.1007/S004360100468
Alain Beschin, Patrick De Baetselier, Jo A Van Ginderachter, Contribution of myeloid cell subsets to liver fibrosis in parasite infection. The Journal of Pathology. ,vol. 229, pp. 186- 197 ,(2013) , 10.1002/PATH.4112
Christian Bogdan, Nitric oxide and the immune response Nature Immunology. ,vol. 2, pp. 907- 916 ,(2001) , 10.1038/NI1001-907
Doaa A. Yones, Gamal A. Taher, Zedan Z. Ibraheim, In Vitro Effects of Some Herbs Used in Egyptian Traditional Medicine on Viability of Protoscolices of Hydatid Cysts Korean Journal of Parasitology. ,vol. 49, pp. 255- 263 ,(2011) , 10.3347/KJP.2011.49.3.255
L.C. Braga, J.W. Shupp, C. Cummings, M. Jett, J.A. Takahashi, L.S. Carmo, E. Chartone-Souza, A.M.A. Nascimento, Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. Journal of Ethnopharmacology. ,vol. 96, pp. 335- 339 ,(2005) , 10.1016/J.JEP.2004.08.034
Asma Bouazza, Arezki Bitam, Malek Amiali, Abdenour Bounihi, Lyece Yargui, Elhadj Ahmed Koceir, Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats. Pharmaceutical Biology. ,vol. 54, pp. 260- 265 ,(2016) , 10.3109/13880209.2015.1031910
Yahya Paksoy, Kemal Ödev, Mustafa Şahin, Ahmet Arslan, Osman Koç, Percutaneous treatment of liver hydatid cysts: comparison of direct injection of albendazole and hypertonic saline solution. American Journal of Roentgenology. ,vol. 185, pp. 727- 734 ,(2005) , 10.2214/AJR.185.3.01850727
Mohammad Moazeni, Ashkan Roozitalab, High scolicidal effect of Zataria multiflora on protoccoleces of hydatid cyst: an in vitro study Comparative Haematology International. ,vol. 21, pp. 99- 104 ,(2012) , 10.1007/S00580-010-1069-3
Sylvia Dematteis, Martin Rottenberg, Adriana Baz, Cytokine response and outcome of infection depends on the infective dose of parasites in experimental infection by Echinococcus granulosus Parasite Immunology. ,vol. 25, pp. 189- 197 ,(2003) , 10.1046/J.1365-3024.2003.00620.X
R. Gracious Ross, S. Selvasubramanian, S. Jayasundar, Immunomodulatory activity of Punica granatum in rabbits--a preliminary study. Journal of Ethnopharmacology. ,vol. 78, pp. 85- 87 ,(2001) , 10.1016/S0378-8741(01)00287-2