Les prostaglandines et l’immunité du chorion sous-muqueux intestinal. Questions à propos de l’usage répété du paracétamol et de l’ibuprofène en bas âge

摘要: Immune deviations have been shown to exponentially increase in young children. As a consequence, research investigating possible environmental reasons for this is considered public health priority. An improved understanding of the immunity intestinal submucosal lamina propria has demonstrated importance prostaglandins (PGE2s) on its local development with general immune consequences further on. PGE2s appear at level from metabolism arachidonic acid mediated by type-2 cyclooxygenases (COX2s) situated membranes many cells. The potential risk repeated inhibition PGE2 synthesis age experiments animals systemically exposed non-steroidal anti-inflammatory drug (NSAID). repeatedly animal cannot develop tolerance food antigens and exhibits autoimmune deviations. Acetaminophen (paracetamol) ibuprofen are analgesic antipyretic medications given children either alone or combination, most often without medical prescription. Recently, it that paracetamol, like ibuprofen, also carries, besides central action, non-selective inhibitory action peripheral COXs. However, only relates physiological concentrations explains difference their respective effects. Since recently published data reported an associated paracetamol exposure age, appears important better understand negative impact excessive repetitive inhibitions COX2s childhood during which all mechanisms built up level. Therefore, well-designed prospective strategy pharmacovigilance these COX inhibitors urgently needed.