A feline model for experimental studies of peritumor brain edema
作者： J. Bayens-Simmonds , D.P.J. Boisvert , M.E. Castro , E.S. Johnson
DOI: 10.1007/BF00177435
关键词: Brain tumor 、 Edema 、 Medicine 、 Glioma 、 In vivo 、 Pathology 、 White matter 、 Magnetic resonance imaging 、 Cerebral edema 、 Intracranial pressure
摘要: An in vivo model for correlative imaging studies of intracerebral glial tumors and peritumor brain edema has been developed. Adult male female cats implanted with 1 × 106 or 5 105 9L glioma cells had parietal 4 mm greater diameter showed signs increased intracranial pressure 13.7±1.9 days 19.2±1.3 after implantation. No immunosuppression was required the success rate tumor growth implantation 88%. Histologically, resembles a malignant astrocytoma. The contained highest water content (85.94%); white matter more edematous (73.01%) than contralateral hemisphere (69.04%), sham-operated (69.41%) control (68.76%). There no correlation between size matter. Increased tissue albumin indicated blood-brain barrier dysfunction within confirmed vasogenic origin edema. Proton magnetic resonance provided good spatial contrast resolution signal intensity matter, decreasing distance from tumor. large this animal allows use serial regional biochemical measurements single animal. Other advantages are its predictability short time to produce marked
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