Sphingolipid biosynthesis in man and microbes.

摘要: A new review covering up to 2018 Sphingolipids are essential molecules that, despite their long history, still stimulating interest today. The reasons for this as well playing structural roles within cell membranes, they have also been shown perform a myriad of signalling functions vital the correct function eukaryotic and prokaryotic organisms. Indeed, sphingolipid disregulation that alters tightly-controlled balance these key lipids has closely linked number diseases such diabetes, asthma various neuropathologies. Sphingolipid biogenesis, metabolism regulation is mediated by large enzymes, proteins second messengers. There appears be core pathway common all sphingolipid-producing organisms but recent studies begun dissect out important, species-specific differences. Many only recently discovered in most cases molecular biochemical details beginning emerge. Where there direct link from classic biochemistry clinical symptoms, drug companies undertaken medicinal chemistry campaign try deliver therapeutic intervention alleviate diseases. appropriate, we highlight targets where natural products exploited useful tools. Taking aspects into account covers structural, mechanistic regulatory features biosynthetic metabolic enzymes.