The role of lectins in allergic sensitization and allergic disease.
作者： Herb F. Sewell , Farouk Shakib , Amir M. Ghaemmaghami , Fabián Salazar
DOI: 10.1016/J.JACI.2013.02.001
关键词: Type I hypersensitivity 、 Galectin 、 Allergen 、 Disease 、 House dust mite 、 Allergy 、 Allergic sensitization 、 Immunology 、 Biology 、 Immunoglobulin E
摘要: Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding molecular basis this group chronic inflammatory disorders remains rather elusive. Recently, role carbohydrates on allergens and their counterstructures antigen-presenting cells (lectins) have been highlighted as crucial factors in allergen sensitization, which culminates TH2 cell differentiation production deleterious specific IgE antibodies. Here we review recent progress different lectins patients with type I hypersensitivity or allergy, interplay other determinants allergenicity, ways developing therapeutic modalities against newly identified targets.
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