The Clinical Significance of Coexpression of Cyclooxygenases-2, Vascular Endothelial Growth Factors, and Epidermal Growth Factor Receptor in Nasopharyngeal Carcinoma

摘要: Objectives/Hypothesis: To investigate the inter-relationship of expressions cyclooxygenases-2 (COX-2), vascular endothelial growth factors (VEGF), and epidermal factor receptor (EGFR) in nasopharyngeal cancer (NPC) cells, their clinical significance association with extent disease at diagnosis. Study Design: Prospective. Methods: Expressions COX-2, VEGF, EGFR protein were detected using immunohistochemistry 111 patients pathologically confirmed stage II to IV carcinoma. The correlation between three tumor markers stages diagnosis investigated. Results: over-expressed 76.6, 66.7, 73.9% NPC respectively. staining patterns was cytoplasmic for membranous EGFR, both COX-2 cells. Linear associations observed intensity vs. or VEGF EGFR. Furthermore, all significantly associated measured by Tumor, Node, Metastasis classification staging grouping American Joint Committee on Cancer/International Union Against Cancer system. Conclusion: cells interrelated, diagnosis. Further investigation is needed determine applications predicting long-term outcome after definitive therapy.