Targeting Receptors, Transporters and Site of Absorption to Improve Oral Drug Delivery

摘要: Although the oral route of drug administration is most acceptable way self-medication with a high degree patient compliance, intestinal absorption many drugs severely hampered by different biological barriers. These barriers comprise biochemical and physical components. The barrier includes enzymatic degradation in gastrointestinal lumen, brush border cytoplasm epithelial cells as well efflux transporters that pump molecules from inside cell back to lumen. consists membranes, tight junctions mucus layer. Different strategies have been applied improve after administration, which range chemical modification formulation technologies targeting receptors, specialized such gut-associated lymphoid tissues. This review focuses specifically on receptor-mediated endocytosis, absorption-site methods optimizing absorption. Intestinal express several nutrient can be targeted modifying molecule it recognized substrate. Receptor-mediated endocytosis transport mechanism for instance linking receptor substrate interest. Many exist enhancing one deliver at specific site tract where optimum takes place.