Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma End Points
作者： Michael J. O??Brien , Shi Yang , Charline Mack , Huihong Xu , Christopher S. Huang
DOI: 10.1097/01.PAS.0000213313.36306.85
关键词: KRAS 、 Pathology 、 DNA methylation 、 CpG Island Methylator Phenotype 、 Adenoma 、 Colorectal cancer 、 Sessile serrated adenoma 、 Biology 、 Microsatellite instability 、 Methylation 、 Cancer research
摘要: The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype (CIMP), microsatellite instability (MSI) status in each the histologic categories, including end-point carcinomas with residual adenoma, serrated polyp neoplasia pathway traditional (nonserrated
sci-hub.se 参考文章(48)
Joanne Young, Lisa A. Simms, Kelli G. Biden, Coral Wynter, Vicki Whitehall, Rozemary Karamatic, Jill George, Jack Goldblatt, Ian Walpole, Sally-Anne Robin, Michael M. Borten, Russell Stitz, Jeffrey Searle, Diane McKeone, Leigh Fraser, David R. Purdie, Kay Podger, Rachael Price, Ron Buttenshaw, Michael D. Walsh, Melissa Barker, Barbara A. Leggett, Jeremy R. Jass, Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. American Journal of Pathology. ,vol. 159, pp. 2107- 2116 ,(2001) , 10.1016/S0002-9440(10)63062-3
Ann Graham Zauber, Richard Komorowski, G.Richard Dickersin, Dennis Kasimian, Leonard S. Gottlieb, Barbara Diaz, Sidney J. Winawer, Stephen Geller, Michael J. O'Brien, Stephen Ewing, Arnold Szporn, Stephen S. Sternberg, The National Polyp Study. Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas. Gastroenterology. ,vol. 98, pp. 371- 379 ,(1990) , 10.5555/URI:PII:001650859090827N
Gabriel Capella, Minoru Toyota, Manel Esteller, Stephen B. Baylin, Miguel Angel Peinado, James G. Herman, Silvia Tortola, Hypermethylation-associated Inactivation of p14ARF Is Independent of p16INK4a Methylation and p53 Mutational Status Cancer Research. ,vol. 60, pp. 129- 133 ,(2000)
H. Iino, J. R. Jass, L. A. Simms, J. Young, B. Leggett, Y. Ajioka, H. Watanabe, DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? Journal of Clinical Pathology. ,vol. 52, pp. 5- 9 ,(1999) , 10.1136/JCP.52.1.5
Seun-Ja Park, Asif Rashid, Jae-Hyuk Lee, Sang Geol Kim, Stanley R. Hamilton, Tsung-Teh Wu, Frequent CpG Island Methylation in Serrated Adenomas of the Colorectum American Journal of Pathology. ,vol. 162, pp. 815- 822 ,(2003) , 10.1016/S0002-9440(10)63878-3
Neal S. Goldstein, Small Colonic Microsatellite Unstable Adenocarcinomas and High-Grade Epithelial Dysplasias in Sessile Serrated Adenoma Polypectomy Specimens American Journal of Clinical Pathology. ,vol. 125, pp. 132- 145 ,(2006) , 10.1309/V8Q9-KDD5-AJ9L-NBAG
Lucian R Chirieac, Lanlan Shen, Paul J Catalano, Jean-Pierre Issa, Stanley R Hamilton, Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation The American Journal of Surgical Pathology. ,vol. 29, pp. 429- 436 ,(2005) , 10.1097/01.PAS.0000155144.53047.7D
Wade S. Samowitz, Hans Albertsen, Jennifer Herrick, Theodore R. Levin, Carol Sweeney, Maureen A. Murtaugh, Roger K. Wolff, Martha L. Slattery, Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer Gastroenterology. ,vol. 129, pp. 837- 845 ,(2005) , 10.1053/J.GASTRO.2005.06.020
Hui Li, Lois Myeroff, Dominic Smiraglia, Michael F Romero, Theresa P Pretlow, Lakshmi Kasturi, James Lutterbaugh, Ronald M Rerko, Graham Casey, Jean-Pierre Issa, Joseph Willis, James KV Willson, Christoph Plass, Sanford D Markowitz, None, SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 8412- 8417 ,(2003) , 10.1073/PNAS.1430846100
Harith Rajagopalan, Alberto Bardelli, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Victor E. Velculescu, Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. ,vol. 418, pp. 934- 934 ,(2002) , 10.1038/418934A