Cardiac function in Wilms' tumor survivors.
作者： K Sorensen , G Levitt , D Sebag-Montefiore , C Bull , I Sullivan
DOI: 10.1200/JCO.1995.13.7.1546
关键词: Doxorubicin 、 Cardiology 、 Surgery 、 Heart disease 、 Chemotherapy 、 Cumulative dose 、 Contractility 、 Afterload 、 Internal medicine 、 Wilms' tumor 、 Cardiac function curve 、 Medicine
摘要: PURPOSETo study late cardiac function in a single diagnostic group (children with Wilms' tumor) good long-term survival; to compare patients treated anthracyclines (doxorubicin) without and normal child/adolescent group; examine the risk factors involved dysfunction.PATIENTS AND METHODSEchocardiographic studies were performed on 97 tumor (mean cumulative dose, 303 mg/m2) mean follow-up time of 7.1 years, 39 8.9 50 subjects. Left ventricular (LV) dimensions, end systolic wall stress (a measure afterload), load-dependent -independent measures contractility compared between groups. Potential factors, including age at diagnosis, duration, sex, pubertal status, irradiation, dose-intensity, dose anthracyclines, studi...
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