A prospective, multi-institutional diagnostic trial to determine pathologist accuracy in estimation of percentage of malignant cells.
作者： Hollis Viray , Kevin Li , Thomas A. Long , Patricia Vasalos , Julia A. Bridge
DOI: 10.5858/ARPA.2012-0561-CP
关键词: Colon tissue 、 Pathology 、 Clinical trial 、 Adenocarcinoma 、 Estimation 、 Medicine 、 Malignant cells 、 Prospective cohort study 、 Diagnostic Trial 、 Magnification
摘要: Context.—The fraction of malignant cells in tumor tissue submitted for tests genetic alterations is a critical variable testing accuracy. That currently determined by pathologist visual estimation the percentage cells. Inaccuracy could lead to false-negative test result. Objective.—To describe prospective, multi-institutional study determine Design.—Ten ×20 magnification images hematoxylin-eosin–stained colon specimens were sent as an educational component College American Pathologists KRAS-B 2011 Survey. Data from 194 labs analyzed and compared criterion standard with comprehensive manual nuclear counts. Results.—Survey responses indicated low interlaboratory precision estimation, but mean estimates fairly accurate. A total 5 10 cases assessed showed more than 10% respondents overestimating manner that results. Conclusions.—The sig...
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