Placental alkaline phosphatase as a tumor marker in ovarian cancer.

摘要: The serum levels of placental alkaline phosphatase were determined with a radioimmunoassay using polyclonal antibody on 1236 samples from 414 patients ovarian cancer. frequencies elevated enzyme for or without evidence disease 17.7 and 10.9%, respectively. true positive rate was highest in serous cystadenocarcinoma, undifferentiated carcinoma, dysgerminoma. A tendency to an inverse correlation differentiation found. Measurement the did not give useful index stage disease, tumor burden, prognosis. value as successful therapy limited because half lost this marker during progression. Further studies use should evaluate modulation pattern course be based monoclonal antibodies.