Epidermal growth factor receptor gene polymorphisms, R497K, but not (CA)n repeat, is associated with dilated cardiomyopathy.
作者： Bin zhou , Li Rao , Ying Peng , Qiuping Zhang , Lin Zhang
DOI: 10.1016/J.CCA.2009.02.014
关键词: Genotype frequency 、 Case-control study 、 Dilated cardiomyopathy 、 Genotype 、 Biology 、 Internal medicine 、 Allele 、 Endocrinology 、 Cardiomyopathy 、 Heart failure 、 Epidermal growth factor 、 Molecular biology
摘要: Background Epidermal growth factor receptor (EGFR) has been recently implicated in pathological tissue remodelling and sustained processes can lead to outcomes, such as cardiac hypertrophy heart failure. Dilated cardiomyopathy (DCM) is the most common form of muscle disease, comprising 60% cases identified cardiomyopathy. This study aimed evaluate association between EGFR gene polymorphisms DCM a Chinese population. Methods Genomic DNA was extracted from whole blood samples 163 patients 185 control subjects. R497K (Arg497Lys) (CA)n were genotyped, difference their allele genotype frequencies distribution controls analyzed. Results No significant observed frequency repeat The Lys significantly higher than that (64.4% 53.8%, controls, respectively p = 0.005, OR 1.556, 95% CI 1.146-2.111). for Lys/Lys overrepresented (p 0.020, 2.105, 1.134-3.905, vs. Arg/Arg). Conclusion suggests polymorphism may be associated with
cabdirect.org
elsevier.com
sci-hub.se 参考文章(43)
G. H. Sato, J. Mendelsohn, J. Polikoff, J. D. Sato, A. D. Le, T. Kawamoto, Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Molecular biology & medicine. ,vol. 1, pp. 511- 529 ,(1983)
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. ,vol. 93, pp. 841- 842 ,(1996) , 10.1161/01.CIR.93.5.841
Gordon Sato, Bonnie Wolf, Tomoyuki Kawamoto, John Mendelsohn, J. Denry Sato, Hideo Masui, Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies Cancer Research. ,vol. 44, pp. 1002- 1007 ,(1984)
Horst Buerger, Frank Gebhardt, Hartmut Schmidt, Burkhard Brandt, Werner Boecker, Kirsten Hutmacher, Alf Beckmann, Ralph Lelle, Ronald Simon, Length and Loss of Heterozygosity of an Intron 1 Polymorphic Sequence of egfr Is Related to Cytogenetic Alterations and Epithelial Growth Factor Receptor Expression Cancer Research. ,vol. 60, pp. 854- 857 ,(2000)
Bin Zhou, Li Rao, Yi Li, Linbo Gao, Cui Li, Yu Chen, Hui Xue, Weibo Liang, Meili lv, Yaping Song, Ying Peng, Lin Zhang, The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. Clinica Chimica Acta. ,vol. 400, pp. 21- 24 ,(2009) , 10.1016/J.CCA.2008.09.028
M B Codd, D D Sugrue, B J Gersh, L J Melton, Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation. ,vol. 80, pp. 564- 572 ,(1989) , 10.1161/01.CIR.80.3.564
Janessa J. Laskin, Alan B. Sandler, Epidermal growth factor receptor: a promising target in solid tumours Cancer Treatment Reviews. ,vol. 30, pp. 1- 17 ,(2004) , 10.1016/J.CTRV.2003.10.002
N. L. Spector, Y. Yarden, B. Smith, L. Lyass, P. Trusk, K. Pry, J. E. Hill, W. Xia, R. Seger, S. S. Bacus, Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 10607- 10612 ,(2007) , 10.1073/PNAS.0701286104
Antonio Araujo, Ricardo Ribeiro, Isabel Azevedo, Ana Coelho, Marta Soares, Berta Sousa, Daniela Pinto, Carlos Lopes, Rui Medeiros, Giorgio V Scagliotti, Genetic Polymorphisms of the Epidermal Growth Factor and Related Receptor in Non-Small Cell Lung Cancer—A Review of the Literature Oncologist. ,vol. 12, pp. 201- 210 ,(2007) , 10.1634/THEONCOLOGIST.12-2-201
T. Moriai, M. S. Kobrin, C. Hope, L. Speck, M. Korc, A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 10217- 10221 ,(1994) , 10.1073/PNAS.91.21.10217