Oligoclonality of CD8+ T cells in breast cancer patients.
作者： Koichi Ito , James Fetten , Houman Khalili , Steven Hajdu , Erna Busch
DOI: 10.1007/BF03401720
关键词: Biology 、 Peripheral blood mononuclear cell 、 T-cell receptor 、 CD8 、 Population 、 Immunology 、 T cell 、 Cytotoxic T cell 、 Cancer research 、 Antigen 、 Interleukin 21
摘要: Substantial evidence has suggested that T cells play an important role in antitumor immunity. with cytotoxic activity against tumors have been isolated from vitro culture of tumor-infiltrated lymphocytes cancer patients. In addition, clonal expansions identified lesions by using a PCR-based CDR3 analysis cell receptors (TCR). Since the region receptor directly interacts antigen-MHC complex and is thus highly polymorphic, dominant length particular TCR V beta population will indicate expansion specific clone. Utilizing this technique, we analyzed repertoire lymph nodes (LNs) peripheral blood 20 breast Our results show most cases, mononuclear (PB-MCs) LN express CD8+ clones different gene families, number higher PBMC than LN. Furthermore, 7 out 16 patients' nodes, there 18 subset. The frequency oligoclonal non-breast 1 9, but no obvious motif can be identified. prevalence dominance found discussed context possible tumor-related antigen stimulation.
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