Prognosis of breast-carcinoma lymphagenesis evaluated by immunohistochemical investigation of vascular-endothelial-growth-factor receptor 3
作者： Jocelyne Jacquemier , Marie-Pierre Mathoulin-Portier , Reija Valtola , Emmanuelle Charafe-Jauffret , Jeannine Geneix
DOI: 10.1002/(SICI)1097-0215(20000120)89:1<69::AID-IJC11>3.0.CO;2-M
关键词: Pathology 、 Immunohistochemistry 、 Lymphatic system 、 Growth factor receptor 、 Breast carcinoma 、 Angiogenesis 、 Lymphatic Endothelium 、 Medicine 、 Carcinoma 、 Mammary gland
摘要: Very few studies have yet addressed the question of existence and role lymphagenesis in tumor growth; it is generally overshadowed by greater emphasis placed on blood vascular system. Monoclonal antibodies against endothelial-growth-factor receptor 3 (VEGFR3) been shown to provide a specific antigenic marker for lymphatic endothelium. By comparison with microvascular count (MVC), we investigated prognostic value microlymphatic (MLC) series 60 cases 2-cm-diameter breast carcinomas. The mean MVC was 72.5 MLC, 40.5. There no quantitative correlation between these 2 parameters. but not MLC had overall survival. Neither nor any axillary-lymph-node invasion.
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