Pharmacogenetics in drug discovery and development: a translational perspective
作者： Allen D. Roses
DOI: 10.1038/NRD2593
关键词: Perspective (graphical) 、 Bioinformatics 、 Pharmacogenetics 、 Drug development 、 Adverse effect 、 Drug response 、 Computational biology 、 Drug discovery 、 Candidate gene 、 Diagnostic test 、 Medicine
摘要: The ability to predict a patient's drug response on the basis of their genetic information is expected decrease attrition during development new, innovative drugs, and reduce adverse events by being able individual patients at risk. Most pharmacogenetic investigations have focused drug-metabolism genes or candidate that are thought be involved in specific diseases. However, robust new tools now enable researchers carry out multi-candidate gene-association genome-wide studies for target discovery development. Despite expanding role pharmacogenetics industry, however, there paucity published data. New forms effective efficient collaboration between industry academia may enhance systematic collection data necessary establish profiles related response, confirm associations expedite drugs diagnostic tests.
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