Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer.
作者： David R Fogelman , Scott Kopetz , Fernando Cabanillas , James L Abbruzzese , Robert A Wolff
DOI:
关键词: Iniparib 、 Poly (ADP-Ribose) Polymerase Inhibitor 、 PARP inhibitor 、 Pancreatic cancer 、 Cancer 、 Pancreatic disease 、 Biology 、 CA19-9 、 Cancer research 、 Gemcitabine
摘要: Pancreatic cancer is an aggressive, frequently fatal malignancy that strikes 37,000 patients annually in the U.S.A. It poorly responsive to standard chemotherapies such as gemcitabine. Approximately 5-10% of pancreatic occurs setting a BRCA2 mutation. Breast and ovarian carcinomas harbor mutations are susceptible effects emerging class targeted agents, namely, poly(ADP-ribose) polymerase (PARP) inhibitors. This report describes case patient with germline mutation associated treated iniparib (BSI-201), PARP inhibitor, who demonstrated complete pathologic response this agent. highlights potential benefit for inhibition BRCA2-related cancer.
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