Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone

摘要: The microstructure of trabecular bone is usually perceived as a collection plate-like and rod-like trabeculae, which can be determined from the emerging high-resolution skeletal imaging modalities such micro-computed tomography (μCT) or clinical peripheral quantitative CT (HR-pQCT) using individual trabecula segmentation (ITS) technique. It has been shown that ITS-based plate rod parameters are highly correlated with elastic modulus yield strength human bone. In current study, plate-rod (PR) finite element (FE) models were constructed completely based on ITS-identified plates rods. We hypothesized PR FE accurately efficiently predict Human cores proximal tibia (PT), femoral neck (FN) greater trochanter (GT) scanned by μCT. Specimen-specific generated for each μCT image corresponding voxel-based also in comparison. Both types specimen-specific subjected to nonlinear analysis apparent same tissue properties. Then, mechanical tests performed experimentally measure strength. Strong linear correlations both (r(2) = 0.97) 0.96) found between model predictions experimental measures, suggesting morphology adequately captures three-dimensional (3D) microarchitecture addition, 0.99, r(2) 0.98, respectively), resulted original 3D images without segmentation. conclusion, predicted across three distinct anatomic sites. Trabecular rods determine