Recurrent respiratory distress syndrome in successive preterm pregnancies

摘要: BACKGROUND: Earlier studies suggesting an increased recurrence risk of respiratory distress syndrome (RDS) among the subsequent infants women with a previously affected infant were based on low birth weight inclusion criteria that did not differentiate between preterm and growth-retarded infants. METHODS: We therefore carried out two cohort who delivered singleton (gestational age <37 completed weeks) infants: 1978 to 1989 at Royal Victoria Hospital (RVH) in Montreal 1959 1966 United States Collaborative Perinatal Project (CPP). compared relative (RR) development RDS second according status first. The diagnosis was more than 24 hours' duration reticulogranular pattern chest radiograph. RESULTS: RVH study sample comprised 284 born 142 women, CPP 642 321 mothers. In crude RR sibling 3.3 (95% confidence interval = 1.0 15.1) whose first had versus those have RDS. corresponding 2.5 0.8 7.9). These elevated risks altered substantially when multiple logistic regression used control for potentially confounding factors known influence age, sex, route delivery, antenatal corticosteroids, depression birth). CONCLUSIONS: conclude previous by are RDS, which suggests important genetic (or other familial) tendency its origin. (J PEDIATR 1996;129:591-6)