Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum

摘要: Abstract Sympathetic postganglionic nerve fibres supplying mesenteric arteries and intrinsic ileal neurones differ in their characteristics of regeneration. Since the latter population occurs predominantly prevertebral ganglia, which have been reported to be spared some extent after treatment with antiserum growth factor (anti-NGF), we investigated whether two populations were differentially sensitive anti-NGF. Newborn rats treated daily for first postnatal week either anti-NGF or 154 mM NaCl solution. At 4 8 weeks age, presence a functional sympathetic innervation gut was determined correlated fluorescence histochemical demonstration noradrenergic fibres. both ages, stimulation extrinsic caused an inhibition motility, while completely lacked innervation. Retrograde labelling cell bodies control confirmed that located prevertebral, superior coeliac ganglia splanchnic lying along greater nerves. By inference from retrograde animals, present all these as well thoracic lumbar paravertebral chains. The results suggest functionally distinct neurones, overlap considerably distributions, are immunological removal NGF.