CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases.

摘要: ChIP-chip and expression analyses indicated that CUX1 transcription factors regulate a large number of genes microRNAs involved in multiple cellular processes. Indeed, proliferating cells was shown to several DNA replication, progression into S phase later, the spindle assembly checkpoint controls through mitosis. siRNA-mediated knockdown established is required for cell motility. Moreover, higher short isoforms, as observed many cancers, stimulate migration invasion. In parallel, elevated particularly grade tumors breast pancreatic cancers implicated tumor initiation progression. transgenic mouse models demonstrated causal role originating from various types. These studies revealed or activity not only stimulates proliferation motility, but also promotes genetic instability. has been etiology polycystic kidney diseases, both approach analysis this disease. Studies neurobiology have uncovered potential implication cognitive disorders, neurodegeneration obesity. be expressed specifically pyramidal neurons neocortex upper layers where it regulates dendrite branching, spine development, synapse formation. addition, modulation hypothalamus associated with changes leptin receptor trafficking vicinity primary cilium resulting altered signaling ultimately, eating behavior. Overall, fields allowed development cell-based assays monitor function extended range organs which plays an important tissue homeostasis.