Role of C-reactive protein in coronary risk reduction: focus on primary prevention.

摘要: Given the limitations of current risk assessment strategies, adjunctive markers are needed to improve prediction a first coronary event. Research into inflammatory nature atherosclerosis suggests that inflammatory-response proteins may serve as potential predictors clinical events. One in particular, C-reactive protein, has been focus much attention. Epidemiologic studies have shown fairly consistent independent association between high-sensitivity protein (hs-CRP) elevations and risk, although causal relation not yet established. this association, guidelines recommend optional use hs-CRP predict enhanced absolute selected patients. The marker general practice should be based on statistical measures show incremental benefit over established factors randomized trials which therapy initiated result screening improves patient outcomes. Thus far, evidence concerning is conclusive. Justification for Use Statins Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) now being conducted compare efficacy statin versus placebo subjects considered at increased basis elevations, despite low normal levels low-density lipoprotein cholesterol. In conclusion, epidemiologic suggest low-grade independently associated with more complete validate tool target individual