Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study.
作者： Andrei Barasch , Monika M Safford , Ingrida Dapkute-Marcus , Daniel H Fine
DOI: 10.1016/J.TRIPLEO.2003.09.005
关键词: Acquired immunodeficiency syndrome (AIDS) 、 Chlorhexidine 、 Mycosis 、 Sida 、 Dentistry 、 Medicine 、 Immunopathology 、 Internal medicine 、 Cross-sectional study 、 Viral disease 、 Antiseptic
摘要: Abstract Purpose We evaluated the effect of chlorhexidine (CHX) 0.12% rinses on clinical and microbiologic manifestations oral candidiasis in HIV-infected children. Study design This was a cross-sectional, intervention study 38 HIV-positive Inclusion based examination positive culture for Candida . At baseline, subjects with no lesions but who were culture-positive (N = 9) placed preventive therapy CHX q.d. 90 days. Subjects therapeutic b.i.d. All received exams at monthly intervals. days mucosal samples again taken Colony-forming units (CFU) determined before after treatment. Results Of 18 subjects, 12 included CFU analyses. After 3 months rinse therapy, undetectable children; another 8 showed an average 2-fold reduction CFU. In 1 child number increased modestly. Overall, pre- posttreatment mean 6.18 ± 2.19 2.73 3.15, respectively ( P .009). Five patients including all had pseudomembranous candidiasis, free signs disease end study. Conclusions suggests that topical disinfectant may be promising agent treating preventing
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