MGMT methylation: A marker of response to temozolomide in low-grade gliomas
作者： Sibille Everhard , Gentian Kaloshi , Emmanuelle Criniere , Alexandra Benouaich‐Amiel , Julie Lejeune
DOI: 10.1002/ANA.21044
关键词: Temozolomide 、 Neoadjuvant therapy 、 Survival rate 、 Glioma 、 Internal medicine 、 Biology 、 Temozolomida 、 Methylation 、 Chemotherapy 、 Oncology 、 Mgmt methylation 、 Immunology
摘要: The methylation status of the O6-methylguanine-methyltransferase promoter (MGMTP) was evaluated in 68 low-grade gliomas treated by neoadjuvant temozolomide. Methylated MGMTP detected 63 (92.6 %) patients and a favorable predictor progression-free survival as compared with unmethylated tumors (p < 0.0001). Assessment could help identifying more likely to respond chemotherapy or benefit from MGMT depletion strategies.
researchgate.net 
sci-hub.se 参考文章(17)
J. Gregory Cairncross, Keisuke Ueki, Magdelena C. Zlatescu, David K. Lisle, Dianne M. Finkelstein, Robert R. Hammond, Jonathan S. Silver, Paul C. Stark, David R. Macdonald, Yasushi Ino, David A. Ramsay, David N. Louis, Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas Journal of the National Cancer Institute. ,vol. 90, pp. 1473- 1479 ,(1998) , 10.1093/JNCI/90.19.1473
Netta Levin, Iris Lavon, Bracha Zelikovitsh, Dana Fuchs, Felix Bokstein, Yakov Fellig, Tali Siegal, Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression. Cancer. ,vol. 106, pp. 1759- 1765 ,(2006) , 10.1002/CNCR.21809
Martin J. van den Bent, Leendert H. J. Looijenga, K. Langenberg, Winand Dinjens, Wilfried Graveland, Ludo Uytdewilligen, Peter A. Sillevis Smitt, Robert B. Jenkins, Johan M. Kros, Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. Cancer. ,vol. 97, pp. 1276- 1284 ,(2003) , 10.1002/CNCR.11187
Michèle Kujas, Julie Lejeune, Alexandra Benouaich‐Amiel, Emmanuelle Crinière, Florence Laigle‐Donadey, Yannick Marie, Karima Mokhtari, Marc Polivka, Michèle Bernier, Fabrice Chretien, Anne Couvelard, Laurent Capelle, Hugues Duffau, Philippe Cornu, Philippe Broët, Joëlle Thillet, Antoine F Carpentier, Marc Sanson, Khê Hoang‐Xuan, Jean‐Yves Delattre, None, Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas. Annals of Neurology. ,vol. 58, pp. 322- 326 ,(2005) , 10.1002/ANA.20543
M.Eva Alonso, M.Josefa Bello, Pilar Gonzalez-Gomez, Dolores Arjona, Jesus Lomas, Jose M de Campos, Alberto Isla, Jose L Sarasa, Juan A Rey, Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas Cancer Genetics and Cytogenetics. ,vol. 144, pp. 134- 142 ,(2003) , 10.1016/S0165-4608(02)00928-7
Maria Möllemann, Marietta Wolter, Jörg Felsberg, V. Peter Collins, Guido Reifenberger, Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. International Journal of Cancer. ,vol. 113, pp. 379- 385 ,(2005) , 10.1002/IJC.20575
Takao Watanabe, Mitsutoshi Nakamura, Johan M. Kros, Christoph Burkhard, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgaki, Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas Acta Neuropathologica. ,vol. 103, pp. 267- 275 ,(2002) , 10.1007/S004010100464
V P Collins, Brain tumours: classification and genes Journal of Neurology, Neurosurgery & Psychiatry. ,vol. 75, pp. ii2- ii11 ,(2004) , 10.1136/JNNP.2004.040337
Sarah Lapointe, Arie Perry, Nicholas A Butowski, Primary brain tumours in adults The Lancet. ,vol. 379, pp. 1984- 1996 ,(2003) , 10.1016/S0140-6736(11)61346-9
Maria F. Paz, Ricard Yaya-Tur, Iñigo Rojas-Marcos, Gaspar Reynes, Marina Pollan, Lucinda Aguirre-Cruz, Jose Luis García-Lopez, Jose Piquer, María-Jose Safont, Carmen Balaña, Montserrat Sanchez-Cespedes, Mercedes García-Villanueva, Leoncio Arribas, Manel Esteller, CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clinical Cancer Research. ,vol. 10, pp. 4933- 4938 ,(2004) , 10.1158/1078-0432.CCR-04-0392