Age-related Changes in Calbindin-D28k, Parvalbumin, and Calretinin Immunoreactivity in the Dog Main Olfactory Bulb
作者： Jung Hoon Choi , Choong Hyun Lee , Ki-Yeon Yoo , In Koo Hwang , In Se Lee
DOI: 10.1007/S10571-009-9425-Z
关键词: Granule cell 、 Calbindin d28k 、 Olfactory system 、 Calretinin 、 Internal medicine 、 Western blot 、 Endocrinology 、 Biology 、 Parvalbumin 、 Olfactory bulb 、 Immunohistochemistry
摘要: Expression and age-related changes of calbindin-D28k (CB), parvalbumin (PV), calretinin (CR) in the main olfactory bulb dog were investigated by immunohistochemistry western blot analysis. Neurons that expressed these calcium-binding proteins showed a characteristic laminar distribution. Most CB-immunoreactive neurons observed glomerular layer (GL) inner sublayer external plexiform (EPL). PV-immunoreactive outer EPL. CR-immunoreactive mainly distributed GL granule cell layer. With regard to changes, stable among all age groups; however, EPL they decreased with age. middle-aged aged groups. However, not These results suggest most sensitive aging, their reduction may be related aging dog.
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