Lungs don't forget: Comparison of the KRAS and EGFR mutation profile and survival of collegiate smokers and never smokers with advanced lung cancers.
作者： Anna M. Varghese , Camelia S. Sima , Jamie E. Chaft , Melissa L. Johnson , Gregory J. Riely
DOI: 10.1097/JTO.0B013E31827914EA
关键词: Former Smoker 、 Internal medicine 、 KRAS 、 Oncology 、 Pathology 、 Smoking cessation 、 Lung 、 Exact test 、 Medicine 、 Never smokers 、 Adenocarcinoma 、 Stage (cooking)
摘要: Background: We hypothesize that among patients with lung cancers the KRAS / EGFR mutation profile and overall survival of collegiate smokers (former who smoked between 101 lifetime cigarettes 5 pack-years) are distinct from those never former 15 pack-years or more. Methods: collected age, sex, stage, survival, smoking history for evaluated 2004 to 2009 advanced stage known status. Mutation were compared using Fisher's exact test log-rank test, respectively. Results: Data available 852 advanced-stage status, which 6% smokers, 36% 30% The (15% mutations, 27% mutations) was ( p = 0.9). Median 25 months, 32 months 0.4), 33 0.48), 21 more 0.63). Conclusions: Collegiate represent a subgroup higher frequency mutations lower smokers. These observations reinforce recommendation routine testing all no degree tobacco exposure is safe.
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