Smoking status and self-reported race affect the frequency of clinically relevant oncogenic alterations in non-small-cell lung cancers at a United States-based academic medical practice

摘要: Abstract Introduction The identification of somatic genomic aberrations in non-small-cell lung cancer (NSCLC) is part evidence-based practice guidelines for care patients with NSCLC. We sought to establish the frequency and correlates these changes routine patient–tumor sample pairs. Methods Clinicopathologic data tumor genotype were retrospectively compiled analyzed from an overall cohort 381 samples. Results Of patients, 75.9% self-reported White race, 13.1% Asian, 6.5% Black, 27.8% never-smokers, 54.9% former-smokers 17.3% current-smokers. EGFR mutations was 23.9% (86/359), KRAS 34.2% (71/207) ALK FISH positivity 9.1% (23/252) samples, almost all had mutually exclusive results oncogenes. In tumors White, Black Asian frequencies 18.4%, 18.2% 62%, respectively; 7.81%, 0% 14.8%, 41.6%, 20% 0%. These patterns changed significant increasing pack-year history smoking. decreased cohorts; while increased. Interestingly, similar never smokers cohorts less than 45pack-year histories smoking only plus cohort. Conclusions , gene abnormalities using tissue samples our United States-based academic medical reflect diverse ethnicity (with a higher patients) inverse correlation between mutation rearrangement) tested population. may help other practices appreciate expected introduction genotyping techniques into their day-to-day