Thyroid hormone-induced expression of the ADP/ATP carrier and its effect on fatty acid-induced uncoupling of oxidative phosphorylation
作者： Peter Schönfeld , Mariusz R Wiêckowski , Lech Wojtczak
DOI: 10.1016/S0014-5793(97)01162-9
关键词: Myristic acid 、 Triiodothyronine 、 Oxidative phosphorylation 、 Internal medicine 、 Phytanic acid 、 ATP–ADP translocase 、 Endocrinology 、 Respiration 、 Biochemistry 、 Chemistry 、 Mitochondrion 、 Fatty acid
摘要: Abstract Liver mitochondria from rats made hypothyroid by administration of 2-mercapto-1-methylimidazole were less sensitive to the uncoupling effect myristic acid, as measured increase resting state respiration, than euthyroid animals, whereas subsequent animals triiodothyronine (`hyperthyroidism') resulted in an increased action myristate. `Hyperthyroidism' also doubling carboxyatractyloside-sensitive portion myristate-stimulated respiration. Parallel this was a twofold mitochondrial content ADP/ATP carrier protein and over threefold its activity. The phytanic acid carboxyatractyloside hyperthyroid smaller extent case These results provide further support thesis [Skulachev, V.P., FEBS Lett. 294 (1991) 158–162] that is involved mechanism long-chain fatty acids.
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