Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: influence of Gleason score, treatment and bone metastasis.
作者： Vanessa Battisti , Liési D.K. Maders , Margarete D. Bagatini , Iara E. Battisti , Luziane P. Bellé
DOI: 10.1016/J.BIOPHA.2012.12.004
关键词: Bone metastasis 、 Metastasis 、 Prostate cancer 、 Cancer 、 Phosphodiesterase 、 Internal medicine 、 Adenosine deaminase 、 Platelet 、 Medicine 、 Adenine nucleotide 、 Endocrinology 、 Cancer research
摘要: The relation between adenine nucleotides and cancer has already been described in literature. Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) adenosine deaminase (ADA) act together to control nucleotide levels, we aimed investigate role of these prostate (PCa). E-NPP ADA activities were determined serum platelets PCa patients controls. We also verified influence Gleason score, bone metastasis treatment enzyme activities. Platelets activity increased, whereas decreased patients. In addition, influenced may propose are involved development PCa. Moreover, modified with distinct metastasis, as well under treatment.
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