Radiation-induced cell cycle arrest compromised by p21 deficiency
作者： James Brugarolas , Chitra Chandrasekaran , Jeffrey I. Gordon , David Beach , Tyler Jacks
DOI: 10.1038/377552A0
关键词: Cell cycle checkpoint 、 Cell cycle 、 Cellular differentiation 、 Cell biology 、 Immunology 、 DNA damage 、 Programmed cell death 、 Biology 、 Fibroblast 、 Apoptosis 、 Proliferating cell nuclear antigen
摘要: … Low to moderate doses of y-irradiation cause cell cycle arrest and p53-dependent … cells regardless of p21 status (Fig. 2d, e). However, as cell cycle arrest in these cells has not …
core.ac.uk
harvard.edu
cshl.edu
nature.com
sci-hub.se 参考文章(23)
E. J. Robertson, Teratocarcinomas and embryonic stem cells : a practical approach IRL Press. ,(1987)
Yong Gu, Christoph W. Turck, David O. Morgan, Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit Nature. ,vol. 366, pp. 707- 710 ,(1993) , 10.1038/366707A0
C.S. Potten, A comprehensive study of the radiobiological response of the murine (BDF1) small intestine. International Journal of Radiation Biology. ,vol. 58, pp. 925- 973 ,(1990) , 10.1080/09553009014552281
Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi, Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes Nature. ,vol. 336, pp. 348- 352 ,(1988) , 10.1038/336348A0
Jeffrey I. Gordon, Michelle L. Hermiston, Differentiation and self-renewal in the mouse gastrointestinal epithelium. Current Opinion in Cell Biology. ,vol. 6, pp. 795- 803 ,(1994) , 10.1016/0955-0674(94)90047-7
Michael B. Kastan, Qimin Zhan, Wafik S. El-Deiry, France Carrier, Tyler Jacks, William V. Walsh, Beverly S. Plunkett, Bert Vogelstein, Albert J. Fornace, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell. ,vol. 71, pp. 587- 597 ,(1992) , 10.1016/0092-8674(92)90593-2
Shou Waga, Gregory J. Hannon, David Beach, Bruce Stillman, The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA Nature. ,vol. 369, pp. 574- 578 ,(1994) , 10.1038/369574A0
Asao Noda, Yi Ning, Susan F. Venable, Olivia M. Pereira-Smith, James R. Smith, Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Experimental Cell Research. ,vol. 211, pp. 90- 98 ,(1994) , 10.1006/EXCR.1994.1063
Wafik S El-Deiry, Takashi Tokino, Victor E Velculescu, Daniel B Levy, Ramon Parsons, Jeffrey M Trent, David Lin, W Edward Mercer, Kenneth W Kinzler, Bert Vogelstein, WAF1, a potential mediator of p53 tumor suppression Cell. ,vol. 75, pp. 817- 825 ,(1993) , 10.1016/0092-8674(93)90500-P
S. Parker, G. Eichele, P. Zhang, A. Rawls, A. Sands, A. Bradley, E. Olson, J. Harper, S. Elledge, P53-independent expression of p21Cip1 in muscle and other terminally differentiating cells Science. ,vol. 267, pp. 1024- 1027 ,(1995) , 10.1126/SCIENCE.7863329