Oncogene addiction in gliomas: Implications for molecular targeted therapy
作者： Wei Yan , Wei Zhang , Tao Jiang
关键词: Oncogene 、 Molecular Targeted Therapies 、 Cancer cell 、 Cancer research 、 Cancer 、 Targeted therapy 、 Glioma 、 Tumor suppressor gene 、 Oncogene Addiction 、 Medicine
摘要: Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation tumor suppressor gene, and regarded as 'Achilles heel' successful molecular targeted therapies in cancer. However, role gliomas has not been elucidated systematically. In this review, we summarize current experimental clinical evidence for concept describe mechanisms explaining gliomas. And implications therapy are further emphasized. addition, discuss future direction defining complex "oncogene network" through integrated analysis multiple platforms flow genetic information gliomagenesis.
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