Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex.
作者： Edgardo R. Parrilla-Castellar , Sonnet J.H. Arlander , Larry Karnitz
DOI: 10.1016/J.DNAREP.2004.03.032
关键词: DNA repair 、 Proliferating cell nuclear antigen 、 Biology 、 Biochemistry 、 CHEK1 、 Replication factor C 、 DNA clamp 、 G2-M DNA damage checkpoint 、 Cell biology 、 Cell cycle checkpoint 、 Origin recognition complex
摘要: Genotoxic stress activates checkpoint signaling pathways that block cell cycle progression, trigger apoptosis, and regulate DNA repair. Studies in yeast humans have shown Rad9, Hus1, Rad1, Rad17 play key roles activation. Three of these proteins-Rad9, Rad1-interact a heterotrimeric complex (dubbed the 9-1-1 complex), which resembles PCNA-like sliding clamp, whereas is part clamp-loading related to PCNA clamp loader, replication factor-C (RFC). In response genotoxic damage, loaded around by Rad17-containing loader. The DNA-bound then facilitates ATR-mediated phosphorylation activation Chk1, protein kinase regulates S-phase G2/M arrest, fork stabilization. addition its role activation, accumulating evidence suggests also participates Taken together, findings suggest multifunctional onto at sites where it coordinates
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