Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts.
作者： K Rygaard , T Nakamura , M Spang-Thomsen
DOI: 10.1038/BJC.1993.7
关键词: Cancer research 、 Gene expression 、 Biology 、 Autocrine signalling 、 Hepatocyte growth factor 、 Stem cell factor 、 Northern blot 、 Growth factor 、 C-Met 、 Nude mouse
摘要: We examined a panel of 25 small cell lung cancer (SCLC) lines and nude mouse xenografts for expression the proto-oncogenes c-met c-kit, corresponding ligands, hepatocyte growth factor (HGF) (also known as scatter (SF)), stem (SCF), respectively. Expression mRNA was detected by Northern blotting, c-kit protein Western blotting immunocytochemistry. expressed in 22 or xenografts, coexpression two observed 20 tumours. paralleled expression. HGF/SF tumours, only one these also proto-oncogene. SCF 19 18 present. The high percentage SCLC tumours expressing indicates that may have an important function this disease. rare is evidence autocrine regulatory pathway not present receptor/ligand system SCLC, while frequent SCLC.
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sci-hub.se 参考文章(49)
R P Narsimhan, L Naldini, P M Comoglio, E Vigna, G K Michalopoulos, G Gaudino, R Zarnegar, Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene. ,vol. 6, pp. 501- 504 ,(1991)
L. Naldini, K.M. Weidner, E. Vigna, G. Gaudino, A. Bardelli, C. Ponzetto, R.P. Narsimhan, G. Hartmann, R. Zarnegar, G.K. Michalopoulos, Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. The EMBO Journal. ,vol. 10, pp. 2867- 2878 ,(1991) , 10.1002/J.1460-2075.1991.TB07836.X
Paolo Comoglio, Silvia Giordano, Maria Flavia Di Renzo, C Rosa, Cs Cooper, Rp Narsimhan, Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene. ,vol. 4, pp. 1383- 1388 ,(1989)
T Hida, R Ueda, K Hibi, H Takagi, Y Ariyoshi, T Takahashi, Y Sekido, Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene. ,vol. 6, pp. 2291- 2296 ,(1991)
P. Blume-Jensen, L. Claesson-Welsh, A. Siegbahn, K.M. Zsebo, B. Westermark, C.H. Heldin, Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. The EMBO Journal. ,vol. 10, pp. 4121- 4128 ,(1991) , 10.1002/J.1460-2075.1991.TB04989.X
Kaoru Shimokata, Yoshitaka Sekido, Toyoaki Hida, Motokazu Suyama, Ryuzo Ueda, Yuichi Obata, Toshitada Takahashi, Yutaka Ariyoshi, Preferential Expression of c-kit Protooncogene Transcripts in Small Cell Lung Cancer Cancer Research. ,vol. 51, pp. 2416- 2419 ,(1991)
Lou de Leij, Pieter E Postmus, Charles HCM Buys, Job D Elema, Frans Ramaekers, S Poppema, Marjolein Brouwer, Anneke Y van der Veen, Geert Mesander, T Hauw The, Characterization of Three New Variant Type Cell Lines Derived from Small Cell Carcinoma of the Lung Cancer Research. ,vol. 45, pp. 6024- 6033 ,(1985)
Y. Yarden, W. J. Kuang, T. Yang-Feng, L. Coussens, S. Munemitsu, T. J. Dull, E. Chen, J. Schlessinger, U. Francke, A. Ullrich, Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. The EMBO Journal. ,vol. 6, pp. 3341- 3351 ,(1987) , 10.1002/J.1460-2075.1987.TB02655.X
John D. Minna, Adi F. Gazdar, Paul J. Marangos, Terry W. Moody, Mark H. Zweig, Gerold Bepler, Desmond N. Carney, John G. Guccion, Establishment and Identification of Small Cell Lung Cancer Cell Lines Having Classic and Variant Features Cancer Research. ,vol. 45, pp. 2913- 2923 ,(1985)
Michael Stoker, Effect of scatter factor on motility of epithelial cells and fibroblasts Journal of Cellular Physiology. ,vol. 139, pp. 565- 569 ,(1989) , 10.1002/JCP.1041390316