The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation.
作者： N Sagata , I Daar , M Oskarsson , S. Showalter , G. Vande Woude
关键词: Proto-Oncogene Proteins c-mos 、 Oocyte 、 Molecular biology 、 Germinal vesicle 、 Biology 、 RNA 、 Cell biology 、 Microinjection 、 Xenopus 、 Maturation promoting factor 、 Gene product
摘要: The endogenous c-mos product, pp39mos, is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase pp39mos that preceded both the activation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection synthetic mos RNA into activated MPF GVBD absence progesterone. Thus, proto-oncogene product may qualify as candidate "initiator" protein at least one "triggers" G2 to M transition.
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