Retrograde regulation of presynaptic development during synaptogenesis.
作者： P. G. Haydon , M. J. Zoran
关键词: Synapse 、 Synaptogenesis 、 Intracellular 、 Growth cone 、 Protein kinase A 、 Biology 、 Signal transduction 、 Postsynaptic potential 、 Excitatory synapse 、 Cell biology 、 Neuroscience
摘要: Major advances are occurring in our understanding of the events leading to synapse formation. Contact between growth cone and target tissue leads intercellular signaling which controls both pre- postsynaptic development synapse. The identity retrograde signals that regulate presynaptic beginning emerge, signal transduction cascades activated presynaptically being characterized. Recent studies have shown resting calcium level activation protein kinase A critical terminal. An these regulatory mechanisms is provide insight into molecular control synaptic specificity.
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