Accelerated and Enhanced Bone Formation on Novel Simvastatin-Loaded Porous Titanium Oxide Surfaces
作者： Myat Nyan , Jia Hao , Takayuki Miyahara , Kanako Noritake , Reena Rodriguez
DOI: 10.1111/CID.12045
关键词: Apposition 、 Osseointegration 、 Simvastatin 、 Bone regeneration 、 Implant 、 Titanium oxide 、 Chemistry 、 Oxide 、 Titanium 、 Dentistry
摘要: Background With increasing application of dental implants in poor-quality bones, the need for implant surfaces ensuring accelerated osseointegration and enhanced peri-implant bone regeneration is increased. Purpose A study was performed to evaluate formation on novel simvastatin-loaded porous titanium oxide surface. Materials Methods Titanium screws were treated by micro-arc oxidation form surface 25 or 50 μg simvastatin loaded. The nontreated control, oxidized, surgically implanted into proximal tibia 16-week-old male Wistar rats (n = 36). Peri-implant volume, bone-implant contact, mineral apposition rates measured at 2 4 weeks. Data analyzed one-way analysis variance followed Tukey's post hoc test. Results New formed directly marrow cavity groups since Bone-implant contact values significantly higher than control oxidized both time points (p < .05). volume rate weeks (p < .05). Conclusions These data suggested that provides faster it would be potentially applicable bones.
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