Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies.
作者： Hee Nam Kim , Yeo-Kyeoung Kim , Il-Kwon Lee , Deok-Hwan Yang , Je-Jung Lee
DOI: 10.1016/J.LEUKRES.2008.07.026
关键词: Oncology 、 Immunology 、 Leukemia 、 Genotype 、 Case-control study 、 Internal medicine 、 Biology 、 Methylenetetrahydrofolate reductase 、 Odds ratio 、 Risk assessment 、 Chronic myelogenous leukemia 、 MTRR
摘要: Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study examine relationship between of and risk AML (acute myelogenous leukemia), CML (chronic MDS (myelodyspastic syndrome), ALL lymphoblastc leukemia). The MTHFR 677TT genotype was an increased for (odds ratios (OR)=1.77; 95% confidence intervals (CI)=1.02-3.09, p=.044). MTRR 66 AG (OR=1.59; 1.06-2.38, p=.026) GG (OR=1.51; 1.03-2.23, p=.037). TYMS 2R3R decreased (OR=0.76; 0.60-0.96, p=.022). hap3 (2R-6bp) hap4 (2R-0bp) were (OR=0.69; 0.53-0.90, p=.006) (OR=1.65; 1.20-2.27, p=.002), respectively AML. Hap C (677T-1298A) (OR=1.40; 1.02-1.92, p=.04) ALL. appears be 677 polymorphism. results are supportive modification by folate several hematologic malignancies Korea. pattern suggests that DNA methylation status both synthesis status.
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