Biology of Flt3 Ligand, a Novel Regulator of Hematopoietic Stem and Progenitor Cells

摘要: Flt3 Ligand (F1t3L) is a protein that plays key role in the regulation of early events development multiple hematopoietic lineages. F1t3L stimulates primitive multipotent precursors, as well more committed or restricted myeloid precursors. has an effect on B cell T development, at least embryo. These effects Flt3L precursors are similar to those observed with Steel factor (SLF), and both these proteins synergize variety cytokines stimulate proliferation cells. However, there number differences between biological two factors, most notable being lack mast Mice lacking receptor have mild defect stem cells isolated from mice impaired ability reconstitute lethally irradiated recipients. Serum levels normally quite low healthy humans (< 100 pg/ml), but highly elevated individuals afflicted anemias component, such Fanconi acquired aplastic anemia, not single lineage anemias, Diamond­Blackfan. data suggest FIt3L may be physiological regulator vivo. find clinical utility treatment disorders, especially involving