Infant stroke and beta-2-glycoprotein 1 antibodies: six cases.
作者： Freja Ebeling , Jari Pet�j� , Soile Alanko , Aune Hirvasniemi , Tarja Holm
DOI: 10.1007/S00431-003-1285-9
关键词: Immunology 、 Thrombin time 、 Antithrombin 、 Antiphospholipid syndrome 、 Lupus anticoagulant 、 Beta 2-Glycoprotein I 、 Antibody 、 Thrombophilia 、 Protein C 、 Medicine
摘要: The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown require a plasma cofactor, beta-2-glycoprotein 1 (β2-GPI). Antibodies against β2-GPI are associated with both venous and arterial thrombosis in adults have suggested as new antiphospholipid syndrome marker. We present six children cerebral at the age 0–12 months, who had IgG (titers 26, 29, 31, 39, 101 109 SGU, when 20 SGU was cut-off). In least four patients, conventional markers (lupus anticoagulant IgM anticardiolipin) were negative. All normal results other routine thrombophilia assays (thrombin time, antithrombin, protein C, S, factor V Leiden mutation, prothrombin mutation). Conclusion: anti-beta-2 glycoprotein assay, requiring only 5 μl serum, may be useful addition antiphospholipid-antibody diagnostics cases paediatric stroke.
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