Chromosome imbalances in familial gliomas detected by comparative genomic hybridization.

摘要: Familial occurrence of gliomas, in the absence well-defined hereditary multisystem disorders, is reported occasionally. We describe 17 families that have been afflicted with two or more gliomas but do not raise suspicion other inheritable syndromes. The were identified among 369 consecutive glioma patients operated at Tampere University Hospital during 1983-1994. applied comparative genomic hybridization (CGH) analysis on 21 occurring these families. most frequent genetic alterations, detected over 20% tumors, losses 6q, 10, 4q, 9p and gains 7, 19, 20q, 1p. compared chromosomal alterations familial to those previously 209 sporadic nine different CGH studies. In this comparison, often showed chromosome arms 4q 6q 1p 22q. (9/21 tumors) resided arm (P = 0.005, Fisher's exact test; Bonferroni correction, P 0.04). loss was also common intrafamilial aberration, present four separate belonging minimal area 6q14-16. conclusion, we found several characteristic aberrations by new regions possibly involved predisposition gliomas.