Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting

摘要: Obesity and its related metabolic disorders, as well infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves enhanced the total antioxidant capacity. The present study investigated influence of a 10-day on markers redox status in 109 subjects. Reducing power, 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation(ABTS) scavenging capacity, hydroxyl capacity increased significantly, indicated an increase circulating levels. No differences were detected superoxide protein carbonyls, dismutase when measured at baseline after 10 days fasting. These findings concomitant to decrease blood glucose, insulin, glycated hemoglobin (HbA1c), cholesterol, low-density lipoprotein (LDL) triglycerides cholesterol/high-density (HDL) ratio. In addition, well-being index subjective energy levels increased, documenting good tolerability. There interplay between parameters since lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) affected ability normalize A machine learning model showed combination predicted efficiency regimen LDL levels. In conclusion, it demonstrated endogenous production molecules, act protectively against free radicals, parallel improved status. Our results suggest outcome strategies could be depending values antioxidative